ABSTRACT
Background: The presence of large number of tonsillectomy surgeries and also the possibility of tonsillar colonization by Helicobacter pylori as the causative agent of tonsillar hypertrophy make it necessary to investigate any possible correlation between the presence of this bacterium and the occurrence of tonsillar hypertrophy
Objective: To investigate the frequency of Helicobacter pylori in chronic tonsillitis patients
Methods: Scorpion real-time PCR was performed on 103 archived paraffin-embedded tonsillar samples collected from patients with tonsillar hypertrophy following tonsillectomy operation at ENT ward of Qods Hospital [Qazvin University of Medical Sciences], Qazvin [Iran] during 2008-2009
Findings: H. pylori DNA was present in 21.35% of total specimens
Conclusion: Although the existence of H. pylori in tonsillar tissue samples of patients with tonsillar hypertrophy is controversial however, it seems that the method by which the laboratory investigation is made may influence the results as the more sensitive and specific scorpion real-time PCR assay showed the tonsils could be considered as important reservoir of H. pylori
ABSTRACT
The roles of inflammatory cytokines and local placental thrombosis in patients with unexplained recurrent spontaneous abortion [URSA] have been shown. Since low molecular weight heparin [LMWH] and acetyl salicylic acid [ASA] have both anti-inflammatory and anti-coagulant effect, we evaluated their efficacy in patients with URSA. One hundred patients with a history of URSA referring to Obstetrics Clinic affiliated to Shiraz University of Medical Sciences between 2004 and 2009 were randomly divided into two groups. Fifty patients in thromboprophylaxis group were treated with LMWH [5000 unit; twice a day], ASA [80 mg daily] and calcium supplement [500 mg daily] after detection of fetal heart beat. Another 50 patients received no thromboprophylaxis. Live birth rate, obstetrical complications, prenatal and neonatal complications and hemorrhagic side effects were recorded. Both groups were matched for mean age and mean number of pervious abortions. Thromboprophylaxis group had a higher rate of live birth [83.7%] in comparison to the control group [54%]. No maternal or neonatal side effects were seen. There were no differences in obstetrical complications, prenatal and neonatal complications between the two groups. Thromboprophylaxis with ASA and LMWH seems to be safe and effective in patients with URSA